Assay Development, Senior Research Scientist

About the Role

We have an immediate opening for a Senior Research Scientist to drive the development of our molecular diagnostics assay platform. The candidate is expected to exercise a broad working knowledge of nucleic acid sample preparation techniques, molecular chemistry, reagent formulation and assay optimization. The ideal candidate will have cross-disciplinary experience in microfluidics and/or fluorescence imaging to participate in system integration activities for our product platform. 

Our ideal candidate has specific interest in developing a novel pathogen detection methodology and wishes to contribute to all aspects of technology development, including bioinformatics, process engineering, automation, and clinical assessment. The candidate will be hands-on in the lab while leading and participating in efforts to develop, implement, validate, and transfer assays for research use and clinical utility. 


  • Develop Melio’s proprietary pathogen identification technology including performance optimization of novel methods.

  • Lead experimental design and automation of molecular biology protocols.

  • Manage interns and laboratory technicians. 

  • Demonstrate strong verbal and written communication skills and periodically communicate results to the cross-disciplinary team.


Required Skills and Experience:

  1. PhD in BioChemistry, Bioengineering, Molecular Biology or a related discipline.

  2. Proven 3+ yr experience with routine molecular biology techniques, such as isolation and quantification of DNA and RNA, DNA sequencing, qPCR , colony PCR, and dPCR.

  3. Expertise in nucleic acid amplification methods and primer design.

  4. Familiarity with DNA extraction and detection methodologies for clinical samples.

  5. Experience with fluorescence imaging.

  6. Experience working with data analysis software, such as Matlab or Python (preferred).

Preferred Skills and Experience

  • Cross-disciplinary expertise with bioinformatics, thermodynamics preferred

  • Experience working with clinical specimens

  • Direct or indirect experience with  microfluidic system design

About the Company

Spun out of UCSD, Melio is a fast growing startup based in the Bay Area. Melio is developing a patented low-cost, benchtop, platform technology to test for common pathogens with the ability to detect novel emerging threats. Melio’s platform builds on the power of AI/machine learning with digital melt analysis for blood culture independent testing in under 3 hours from sample collection.